A probiotic dairy product containing L. gasseri CECT5714 and L. coryniformis CECT5711 induces immunological changes in children suffering from allergy.
Martínez-Cañavate, A., Sierra, S., Lara-Villoslada, F., Romero, J., Maldonado, J., Boza, J., Xaus, J., and Olivares, M.
Pediatr Allergy Immunol – 01-SEP-2009; 20(6): 592-600
Objectives: To evaluate the efficacy of a dairy-based probiotic to alter immunoregulation in children with allergies.
Methods: 44 patients were randomly distributed in a double blind comparative study. Both groups consumed 200 mL of a fermented dairy product (yogurt) for 3 months. The treatment group consumed a product where Lactobacillus bulgaricus was replaced by a mixture of Lactobacillus gasseri CECT5714 and Lactobacillus coryniformis CECT5711. The mixture contained at least 106 CFU/g of each strain. Parameters (serum IgE, CD4/CD25 regulatory T cells, eosinophils, basophils, NK cells and mucosal sIgA) were measured in fecal samples, blood and serum.
Results: The treatment group consuming the yogurt with L. gasseri plus L. bulgaricus showed a significant decrease in IgE (p=0.03). Further, there was an increase in CD4/CD25 regulatory T (p= 0.01) cells and NK cells (p=0.03) with no increase in eosinophils or basophils. Secretory IgA (sIgA) was also increased (p=0.01).
Conclusions: The use of probiotics in children can have beneficial effects on the immune parameters important in the development of an allergic immune response. Innate and acquired immune parameters were positively affected by the use of yogurt supplemented with L. gasseri plus L. bulgaricus.